The Metabolism of 3,4-Benzpyrene into 8- and Benzpyrenols in the Animal Body 10-

Peacock and his collaborators (12-15, 19) showed that injection of 3,4-benzpyrene into various animals caused a phenolic derivative to appear in the excreta. Further investigation by the present authors led to the recognition of 8-benzpyrenol in the feces of benzpyrene-injected mice and rats, associated with 3,4benzpyrene-5,8-quinone (2, 3). experiment (i. e., until the feces were free from chlorophyll and related colored substances that would have interfered with the subsequent chromatography), and the same diet was maintained during the experiment. This diet consisted of bread once a week, bran 3 times a week, oats 3 times a week, and water daily. Though such a diet may not be adequate for the rabbit when ad-